Bookedited by Robert A. Goodnow, Jr.
Contents:
Just enough knowledge?
A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry
A history of DNA-encoding
DNA-compatible chemistry
Foundations of a DNA-encoded library (DEL)
Practices for synthesizing DNA-encoded libraries
Chemical gene design for DNA-encoded libraries
Analytical challenges for DNA-encoded library systems
Information technology: functionality and architectures for DNA-encoding
Theoretical considerations of the application of DNA-encoded libraries to drug discovery
Begin with the end in mind : the hit-to-lead process
Enumeration and visualization of large combinatorial chemical libraries
Screening large compound collections
Reported applications of DNA-encoded library chemistry
Dual-pharmacophore DNA-encoded chemical libraries
Hit identification and hit follow-up
Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding
An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches
Keeping the promise? an outlook on dna chemical library technology.